中枢给予促甲状腺激素释放激素对大鼠血压、心率及通气的影响。

The effect of centrally administered TRH on blood pressure, heart rate and ventilation in rat.

作者信息

Koivusalo F, Paakkari I, Leppäluoto J, Karppanen H

出版信息

Acta Physiol Scand. 1979 May;106(1):83-6. doi: 10.1111/j.1748-1716.1979.tb06373.x.

DOI:10.1111/j.1748-1716.1979.tb06373.x

Abstract

Different doses (3, 16, 80, 400 and 2 000 ng per rat) of TRH or alternatively saline were infused into the lateral ventricle of urethane-anaesthetized rats and blood pressure, heart rate, respiration rate and tidal volume were recorded. A dose of 3 ng TRH caused a significant elevation of blood pressure and heart rate, whereas 16 ng was needed for respiration rate to be elevated. There was no change in respiratory minute volume during the experiment. We conclude that TRH has profound physiological effects and that TRH, given centrally, is a potent hypertensive, chronotropic and tachypnoeic agent.

摘要

将不同剂量（每只大鼠3、16、80、400和2000纳克）的促甲状腺激素释放激素（TRH）或生理盐水注入经乌拉坦麻醉的大鼠侧脑室，并记录血压、心率、呼吸频率和潮气量。3纳克剂量的TRH可使血压和心率显著升高，而呼吸频率升高则需要16纳克。实验过程中每分通气量无变化。我们得出结论，TRH具有深远的生理效应，并且经中枢给予时，TRH是一种强效的升压、变时性和促呼吸剂。