Paakkari I, Siren A L, Nurminen M L, Svartström-Fraser M
Eur Heart J. 1987 May;8 Suppl B:147-51. doi: 10.1093/eurheartj/8.suppl_b.147.
Thyrotropin releasing hormone (TRH), 10 pmol kg-1 injected in the region of locus coeruleus, caused a rapid (within 1 min) rise of mean arterial pressure in the urethane-anaesthetized rat. No clear-cut effects in heart rate or ventilation were observed. When TRH was injected into the lateral ventricle, a dose more than 10-fold higher was required to achieve a comparable rise in arterial pressure. It is concluded that TRH may have a physiological role in central cardiovascular regulation.
在蓝斑区域注射促甲状腺激素释放激素（TRH），剂量为10 pmol kg-1，可使经乌拉坦麻醉的大鼠平均动脉压迅速（1分钟内）升高。未观察到对心率或通气有明显影响。当将TRH注入侧脑室时，需要超过10倍以上的剂量才能使动脉压产生类似程度的升高。由此得出结论，TRH可能在中枢心血管调节中具有生理作用。
