促甲状腺激素释放激素对麻醉大鼠的心肺作用：脑干的作用

Cardioventilator effects of TRH in anaesthetized rats: role of the brain stem.

作者信息

Paakkari I, Nurminen M L, Sirén A L

出版信息

Eur J Pharmacol. 1986 Mar 11;122(1):131-4. doi: 10.1016/0014-2999(86)90168-8.

Abstract

Cardioventilator responses were studied in anaesthetized rats after injections of TRH into either the lateral (i.c.v. lat) or the fourth (i.c.v. IV) cerebral ventricles. TRH induced a more rapid hypertensive effect i.c.v. IV than i.c.v. lat. Blocking of the cerebral aqueduct abolished the hypertensive and tachypnoeic effects of TRH i.c.v. lat but not those of TRH i.c.v. IV. It is concluded that TRH increased blood pressure and ventilation rate via brain stem structures close to the fourth ventricle.

摘要

在麻醉大鼠中，向侧脑室（脑室内侧，i.c.v. lat）或第四脑室（脑室内第四脑室，i.c.v. IV）注射促甲状腺激素释放激素（TRH）后，研究了心血管和通气反应。TRH脑室内第四脑室注射比脑室内侧注射诱发的高血压效应更快。阻断中脑导水管消除了TRH脑室内侧注射的高血压和呼吸急促效应，但未消除TRH脑室内第四脑室注射的这些效应。得出的结论是，TRH通过靠近第四脑室的脑干结构升高血压和通气率。