Gökbuget N, Hoelzer D, Arnold R, Böhme A, Bartram C R, Freund M, Ganser A, Kneba M, Langer W, Lipp T, Ludwig W D, Maschmeyer G, Rieder H, Thiel E, Weiss A, Messerer D
German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia, Frankfurt, Germany.
Hematol Oncol Clin North Am. 2000 Dec;14(6):1307-25, ix. doi: 10.1016/s0889-8588(05)70188-x.
The German Multicenter Study Group for Adult Acute Lymphoblastic leukemia (GMALL) has conducted 5 consecutive trials with more than 3000 patients since 1981. This article provides an overview on aims, treatment concepts, and results of these studies. It includes brief summaries on the development of prognostic models within the GMALL group and on approaches for prophylaxis of CNS relapse, and it summarizes specific treatment concepts for mature B-lineage acute lymphocytic leukemia.
自1981年以来，德国成人急性淋巴细胞白血病多中心研究组（GMALL）已连续开展了5项试验，涉及3000多名患者。本文概述了这些研究的目的、治疗理念和结果。其中包括GMALL组内预后模型的发展以及中枢神经系统复发预防方法的简要总结，还总结了成熟B系急性淋巴细胞白血病的具体治疗理念。
