Lee J S, Jung J J, Kim J
Department of Pathology and Parasitology, Seonam University, College of Medicine, Namwon, Korea.
Anal Quant Cytol Histol. 2000 Dec;22(6):469-74.
To ascertain whether tumor angiogenesis quantitated by a computerized image analysis system correlates with clinical outcome in renal cell carcinoma.
Microvessels were immunohistochemically labeled with antibodies to CD34 in sections from 62 cases of renal cell carcinoma. Computerized image analysis was used to evaluate the mean microvessel count (MMC) and mean percentage microvessel area (MPMA).
MMC ranged from 19.3 to 315.0, while MPMA was 0.6-17.9%. There was a highly significant correlation between MMC and MPMA (r = .867, P < .01). Although MMC and MPMA decreased with increasing nuclear grade and TNM stage, this difference failed to achieve statistical significance. No statistically significant differences in survival were found for MMC or MPMA.
Our results indicate that computerized image analysis can evaluate accurately tumor angiogenesis, but tumor angiogenesis in renal cell carcinoma does not provide significant prognostic information in renal cell carcinoma.
确定通过计算机图像分析系统定量的肿瘤血管生成与肾细胞癌临床结局是否相关。
用抗CD34抗体对62例肾细胞癌切片中的微血管进行免疫组化标记。采用计算机图像分析评估微血管平均计数（MMC）和微血管平均面积百分比（MPMA）。
MMC范围为19.3至315.0，而MPMA为0.6 - 17.9%。MMC与MPMA之间存在高度显著相关性（r = 0.867，P < 0.01）。尽管MMC和MPMA随核分级和TNM分期增加而降低，但这种差异未达到统计学显著性。MMC或MPMA在生存率方面未发现统计学显著差异。
我们的结果表明计算机图像分析能够准确评估肿瘤血管生成，但肾细胞癌中的肿瘤血管生成并不能为肾细胞癌提供显著的预后信息。
