Weber W, Henkes H, Felber S, Jänisch W, Woitalla D, Kühne D
Klinik für Radiologie und Neuroradiologie, Alfried-Krupp-Krankenhaus, Alfried-Krupp-Strasse 21, 45117 Essen.
Radiologe. 2000 Nov;40(11):1017-28. doi: 10.1007/s001170050874.
The hematogenous spread of bacteria, fungi and protozoa may also reach the brain vessels, which happens mostly through septic emboli. From such an embolus a metastatic focal encephalitis and later a septic-embolic brain abscess may arise. The most frequently underlying infections that may cause septic emboli are bacterial endocarditis as well as bacterial infections of artificial heart valve prostheses. Congenital heart malformations with a right-to-left shunt also play here a certain role. Basically, however, all septic conditions and bacteriemias may cause septic-embolic brain abscesses. They occur frequently as multiple lesions. MRI is superior to CT in depicting the different stages of evolution from focal encephalitis, through the hardly encapsulated early abscess, to the formation of a membrane and later a dense fibrous capsule. The medical treatment of a brain abscess requires properly performed CT or MRI follow-up examinations in order to realize early enough a possible growing of such a lesion.
细菌、真菌和原生动物的血源性传播也可能累及脑血管,这主要通过脓毒性栓子发生。从这样的栓子可能会引发转移性局灶性脑炎,随后形成脓毒性栓塞性脑脓肿。最常导致脓毒性栓子的潜在感染是细菌性心内膜炎以及人工心脏瓣膜假体的细菌感染。伴有右向左分流的先天性心脏畸形在这里也起一定作用。然而,基本上所有的脓毒症和菌血症都可能导致脓毒性栓塞性脑脓肿。它们常表现为多发性病变。在描绘从局灶性脑炎到几乎未形成包膜的早期脓肿,再到形成包膜以及后来形成致密纤维性包膜的不同演变阶段方面,MRI优于CT。脑脓肿的药物治疗需要正确进行CT或MRI随访检查,以便尽早发现这种病变可能的增大情况。