Lee D K, Kim D G, Choe G, Chi J G, Jung H W
Department of Neurosurgery, Seoul National University College of Medicine, Korea.
J Neurosurg. 2001 Jan;94(1):122-6. doi: 10.3171/jns.2001.94.1.0122.
The authors present a case of chordoid meningioma in a 55-year-old woman who manifested headache and personality change. Magnetic resonance imaging of the brain and cerebral angiography demonstrated a mass in the right frontal lobe that resembled a typical convexity meningioma. However, the pathological diagnosis was chordoid meningioma, a rare subtype of this tumor that usually occurs in adolescence and is known to be associated with Castleman syndrome. A meningothelial meningiomatous pattern suggestive of a meningothelial origin was focally present, and cytokeratin-positive squamoid cells were noted in the tumor. The lesion lacked dense infiltration of lymphocytes and plasma cells. Polyclonal gammopathy was the only sign of Castleman syndrome and hypochromic microcytic anemia was absent in this case. Polyclonal gammopathy resolved completely 6 months after total removal of the mass.
作者报告了一例55岁女性的脊索样脑膜瘤病例，该患者表现为头痛和性格改变。脑部磁共振成像和脑血管造影显示右额叶有一个肿块，类似于典型的凸面脑膜瘤。然而，病理诊断为脊索样脑膜瘤，这是该肿瘤的一种罕见亚型，通常发生在青少年时期，已知与卡斯尔曼病相关。肿瘤局部存在提示脑膜上皮起源的脑膜上皮型脑膜瘤模式，并且在肿瘤中发现了细胞角蛋白阳性的鳞状细胞。病变缺乏淋巴细胞和浆细胞的密集浸润。多克隆丙种球蛋白病是卡斯尔曼病的唯一征象，且该病例无低色素小细胞性贫血。肿块完全切除6个月后，多克隆丙种球蛋白病完全消退。
