可变取代烯烃支架文库的溶液相合成：烯丙基胺文库
Solution phase synthesis of libraries of variably substituted olefin scaffolds: a library of allylic amines.
作者信息
Organ M G, Mayhew D, Cooper J T, Dixon C E, Lavorato D J, Kaldor S W, Siegel M G
机构信息
Department of Chemistry, York University, 4700 Keele Street, Toronto, Ontario, M3J 1P3, Canada.
出版信息
J Comb Chem. 2001 Jan-Feb;3(1):64-7. doi: 10.1021/cc0000601.
PMID:11148064
Abstract
The synthesis of allylic amine libraries derived from olefin templates is described. The two-step, solution phase reaction sequence consists of amination of the template followed by Suzuki coupling and expedited purification via ion exchange chromatography. The methodology has been used to synthesize a 1344-member allylic amine library.
摘要
本文描述了从烯烃模板衍生的烯丙基胺文库的合成。两步溶液相反应序列包括模板的胺化，随后是铃木耦合反应，并通过离子交换色谱法进行快速纯化。该方法已用于合成一个包含1344个成员的烯丙基胺文库。
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