关于脒盐胺交换反应、硼氢化物还原及后续转化的进一步研究。
Further studies on vinamidinium salt amine exchange reactions, borohydride reductions and subsequent transformations.
作者信息
Gupton John T, Telang Nakul, Jia Xin, Giglio Benjamin C, Eaton James E, Barelli Peter J, Hovaizi Mona, Hall Kayleigh E, Welden R Scott, Keough Matthew J, Worrall Eric F, Finzel Kara L, Kluball Emily J, Kanters Rene P F, Smith Timothy M, Smith Stanton Q, Nunes Shane R, Wright Mathew T, Birnstihl Jennifer M
机构信息
Department of Chemistry, University of Richmond, Richmond, VA 23173, USA.
出版信息
Tetrahedron. 2010 Oct 30;66(44):8485-8493. doi: 10.1016/j.tet.2010.08.075.
Studies directed at the amine exchange reaction of vinamidinium salts followed by sodium borohydride reduction to secondary and tertiary allylic amines are described. The tertiary allylic amines were alkylated and subjected to base mediated rearrangement to yield a variety of highly functionalized tertiary homoallylic amines.
本文描述了针对亚乙烯基脒盐的胺交换反应，随后用硼氢化钠还原为仲烯丙基胺和叔烯丙基胺的研究。叔烯丙基胺经过烷基化并进行碱介导的重排反应，以生成多种高度官能化的叔高烯丙基胺。
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