Baker K B, Montgomery E B
Departments of Neurology and Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, OH, USA.
Neurology. 2001 Jan 9;56(1):25-30. doi: 10.1212/wnl.56.1.25.
To determine whether there is a greater prevalence of asymptomatic first-degree relatives (FDR) of patients with progressive supranuclear palsy (PSP) performing abnormally on the PD test battery (PD Battery) compared to sex- and age-matched normal control (NC) individuals. The PD Battery incorporates tests of motor function, olfaction, and mood. It has high specificity and sensitivity in distinguishing mildly affected PD patients from NC individuals in previous studies.
This test battery and regression analysis-derived scoring equations were applied to asymptomatic FDR.
Twenty-three FDR and 23 NC individuals were tested. Of the FDR, 39% scored in the abnormal range, whereas none of the NC individuals achieved abnormal scores. This difference was significant. Further analysis demonstrated that the two groups differed significantly on a measure of simple reaction time.
The proportion of FDR who demonstrated abnormal performance on the PD Battery was greater than NC individuals. Thus, the PD Battery may detect the asymptomatic carrier state or risk for PSP or a subclinical effect of a shared environmental exposure.
确定与性别和年龄匹配的正常对照（NC）个体相比，进行性核上性麻痹（PSP）患者的无症状一级亲属（FDR）在帕金森病测试组合（PD组合）上表现异常的比例是否更高。PD组合包括运动功能、嗅觉和情绪测试。在先前的研究中，它在区分轻度受影响的帕金森病患者和NC个体方面具有高特异性和敏感性。
该测试组合和回归分析得出的评分方程应用于无症状FDR。
对23名FDR和23名NC个体进行了测试。在FDR中，39%的人得分在异常范围内，而NC个体中无人得分异常。这种差异具有显著性。进一步分析表明，两组在简单反应时间测量上有显著差异。
在PD组合上表现异常的FDR比例高于NC个体。因此，PD组合可能检测到PSP的无症状携带状态或风险，或共同环境暴露的亚临床效应。
