Montgomery E B, Baker K B, Lyons K, Koller W C
Department of Neurology, Lerner Research Institute, Cleveland Clinic Foundation, OH 44195, USA.
Neurology. 1999 Mar 10;52(4):757-62. doi: 10.1212/wnl.52.4.757.
To determine whether a sensitive and specific battery of tests (PD Battery) could identify a subset of asymptomatic first-degree relatives (FDRs) of PD patients who were significantly more impaired than age-matched normal control (NC) subjects. The PD Battery incorporates tests of motor function, olfaction, and mood. In previous studies, it has shown high specificity and sensitivity in distinguishing mildly affected PD patients from NC subjects.
The PD Battery and regression analysis-derived scoring equations were applied to asymptomatic FDRs.
Eighty FDRs and 100 NC subjects were tested. Of the FDRs, 22.5% scored in the abnormal range, and 9% of NC subjects had abnormal scores. This difference was statistically significant. Further analysis demonstrated that FDRs with abnormal scores on the PD Battery differed on all three components of the test battery from FDRs who had normal scores. Among the sons and daughters whose scores were abnormal, there was a much higher prevalence of the affected parent being the father.
The proportion of FDRs who demonstrated abnormal performance on the PD Battery was greater than that of NC subjects. Thus, the PD Battery may detect the asymptomatic carrier state or risk for PD. Sons and daughters whose scores were in the abnormal range were more likely to have fathers with PD.
确定一组敏感且特异的测试（帕金森病测试组合）能否识别出帕金森病患者无症状的一级亲属（FDRs）中比年龄匹配的正常对照（NC）受试者受损程度明显更严重的一个亚组。帕金森病测试组合包括运动功能、嗅觉和情绪测试。在先前的研究中，它在区分轻度受影响的帕金森病患者和NC受试者方面显示出高特异性和敏感性。
将帕金森病测试组合和回归分析得出的评分方程应用于无症状的FDRs。
对80名FDRs和100名NC受试者进行了测试。在FDRs中，22.5%的人得分在异常范围内，而9%的NC受试者得分异常。这种差异具有统计学意义。进一步分析表明，帕金森病测试组合得分异常的FDRs在测试组合的所有三个组成部分上与得分正常的FDRs不同。在得分异常的子女中，患病父母为父亲的患病率要高得多。
在帕金森病测试组合中表现异常的FDRs比例高于NC受试者。因此，帕金森病测试组合可能检测出帕金森病的无症状携带状态或患病风险。得分在异常范围内的子女更有可能有患帕金森病的父亲。
