Bollag R J, Siegfried Z, Cebra-Thomas J A, Garvey N, Davison E M, Silver L M
Department of Molecular Biology, Princeton University, New Jersey 08544.
Nat Genet. 1994 Jul;7(3):383-9. doi: 10.1038/ng0794-383.
The T locus encodes a product with DNA binding activity that is likely to play a role in the development of all vertebrate organisms. We have identified and characterized a novel family of mouse genes that share a protein motif, the T-box, with the prototypical T locus. The T-box domain of the T locus co-localizes with its DNA binding activity. Each T-box gene is expressed in a unique temporal and spatial pattern during embryogenesis. Phylogenetic analysis suggests that at least three T-box genes were present in the common ancestor to vertebrates and invertebrates. Thus, members of the T-box family could have played a role in the evolution of all metazoan organisms.
T基因座编码一种具有DNA结合活性的产物，该产物可能在所有脊椎动物的发育中发挥作用。我们已经鉴定并表征了一个新的小鼠基因家族，这些基因与典型的T基因座共享一个蛋白质基序，即T盒。T基因座的T盒结构域与其DNA结合活性共定位。每个T盒基因在胚胎发育过程中以独特的时间和空间模式表达。系统发育分析表明，脊椎动物和无脊椎动物的共同祖先中至少存在三个T盒基因。因此，T盒家族的成员可能在所有后生动物的进化中发挥了作用。
