Nazli O, Bozdag A D, Tansug T, Kir R, Kaymak E
Atatürk Training Hospital 3. Surgical Clinic Izmir, Turkey.
Hepatogastroenterology. 2000 Nov-Dec;47(36):1750-2.
BACKGROUND/AIMS: CA 19-9 and CEA were evaluated for their specificity and sensitivity in the early diagnosis of pancreatic carcinoma.
This prospective study included 40 patients with pancreatic carcinoma. A control group of 60 patients were divided into two subgroups as upper gastrointestinal system malignancies and benign pancreatic disorders. CEA and CA 19-9 levels were measured in all the patients.
When the reference value of CA 19-9 was accepted as 74 U/mL, the specificity was 100% when pancreatic carcinoma was compared with benign disorders of the pancreas, but it's specificity for upper gastrointestinal malignancies was 60-90%. When the reference value of CEA was increased, the sensitivity had been decreased but the specificity had been increased when compared with the control group. If the reference value of CEA was accepted as 5 ng/mL, the specificity was 100% when pancreatic carcinoma was compared with acute or chronic pancreatitis, but it is less specific for the differential diagnosis of pancreatic carcinoma from the upper gastrointestinal malignancies.
With the progression of the pancreatic carcinoma, serum CEA level and the specificity of CEA were elevated similar to that of CA 19-9. However, the elevation of CEA specificity when compared with the control group was lower than the specificity of the CA 19-9 and the sensitivity of CA 19-9 was superior to that of CEA for pancreatic carcinoma. The level of CA 19-9 was increased with the development of early pancreatic cancer and this elevation steadily continued with the progression of the cancer.
背景/目的：评估CA 19-9和癌胚抗原（CEA）在胰腺癌早期诊断中的特异性和敏感性。
这项前瞻性研究纳入了40例胰腺癌患者。60例患者的对照组被分为两个亚组，即上消化道系统恶性肿瘤和胰腺良性疾病。对所有患者测定CEA和CA 19-9水平。
当将CA 19-9的参考值设定为74 U/mL时，与胰腺良性疾病相比，胰腺癌诊断的特异性为100%，但对上消化道恶性肿瘤的特异性为60%-90%。当CEA参考值升高时，与对照组相比，敏感性降低但特异性升高。如果将CEA参考值设定为5 ng/mL，与急性或慢性胰腺炎相比，胰腺癌诊断的特异性为100%，但在鉴别胰腺癌与上消化道恶性肿瘤方面特异性较低。
随着胰腺癌进展，血清CEA水平及其特异性与CA 19-9类似升高。然而，与对照组相比，CEA特异性的升高低于CA 19-9，且CA 19-9对胰腺癌的敏感性优于CEA。CA 19-9水平随着早期胰腺癌的发展而升高，且随着癌症进展持续稳定升高。
