Lopatkin N A, Ziborova I V, Sivkov A V, Apolikhin O I
Urol Nefrol (Mosk). 1999 Jan-Feb(1):22-6.
The paper is concerned with general cost-effective approaches to management of BPH: problems of treatment and patients choice, cost of different treatments, examinations, time of the response onset, effective doses, regimens, side effects. Mathematical estimations show that of three groups of drugs (alpha 1-adrenoblockers, phytopreparations, finasteride), alpha 1-adrenoblockers are most effective as to minimal time to the start of clinical effect, while once-a-day regimen was the cheapest of the dose regimens. Of alpha 1-adrenoblockers, hemodynamically low-active preparations (tamsulosin) are preferable.
本文关注良性前列腺增生(BPH)管理的一般成本效益方法:治疗问题与患者选择、不同治疗方法的成本、检查、起效时间、有效剂量、治疗方案及副作用。数学估计表明,在三组药物(α1-肾上腺素能阻滞剂、植物制剂、非那雄胺)中,就达到临床效果的最短时间而言,α1-肾上腺素能阻滞剂最为有效,而每日一次的治疗方案是所有剂量方案中最便宜的。在α1-肾上腺素能阻滞剂中,血流动力学低活性制剂(坦索罗辛)更为可取。