Nestor P, Hodges J
University Department of Neurology, Addenbrooke's Hospital, Cambridge, England.
Semin Neurol. 2000;20(4):439-46. doi: 10.1055/s-2000-13176.
The past decade has seen a considerable resurgence of interest in non-Alzheimer forms of neurodegenerative dementia. Advances in our understanding and classification of these conditions have taken place over a diverse range of disciplines: from genetics and immunohistochemistry to neuropsychology and psychiatry. The aim of this article is to review, from a clinician's perspective, our current understanding of the major degenerative dementias that fall into the differential diagnosis of Alzheimer's disease. The clinical variants of frontotemporal dementia (semantic dementia, progressive nonfluent aphasia, and dementia of a frontal type), amyotrophic lateral sclerosis associated dementia, corticobasal degeneration, and dementia with Lewy bodies are considered.
在过去十年中，对非阿尔茨海默病形式的神经退行性痴呆的兴趣显著复苏。我们对这些病症的理解和分类在从遗传学和免疫组化到神经心理学和精神病学等广泛学科领域取得了进展。本文的目的是从临床医生的角度回顾我们目前对属于阿尔茨海默病鉴别诊断的主要退行性痴呆的理解。本文将探讨额颞叶痴呆的临床变体（语义性痴呆、进行性非流利性失语症和额叶型痴呆）、肌萎缩侧索硬化症相关痴呆、皮质基底节变性以及路易体痴呆。
