Safar M E, London G M, Weiss Y A, Milliez P L
Am Heart J. 1975 Apr;89(4):480-6. doi: 10.1016/0002-8703(75)90155-6.
Pressor response to norepinephrine, cardiopulmonary blood volume, and hemodynamic parameters were studied in 41 borderline hypertensive patients in comparison with 42 permanent essential hypertensive patients and 28 normal subjects. Borderline hypertensive subjects had high cardiac index (p less than 0.0001), normal total peripheral resistance, and low total blood volume (p less than 0.005). The ratio between cardiopulmonary blood volume (CPBV) and total blood volume (TBV) was significantly higher in comparison with normal subjects (p less than 0.01) and permanent hypertensive subjects subjects (p less than 0.0001). The pressor dose of norepinephrine was elevated (p less than 0.0001) and was directly correlated with the basal values of the cardiac output (p less than 0.005), the cardiopulmonary blood volume (p less than 0.001), and the CPBV/TBV ratio (p less than 0.01). None of these results was observed in permanent hypertensive subjects: the only significant result was a negative correlation between the pressor dose of norepinephrine and the basal diastolic arterial pressure (p less than 0.0001). This study provides evidence that the cardiac output elevation in borderline hypertensive subjects was related to increased venous return and enhanced sympathetic venous tone.
对41例临界高血压患者、42例持续性原发性高血压患者和28例正常受试者，研究了去甲肾上腺素的升压反应、心肺血容量和血流动力学参数。临界高血压受试者心脏指数较高（p<0.0001），总外周阻力正常，总血容量较低（p<0.005）。与正常受试者（p<0.01）和持续性高血压受试者（p<0.0001）相比，心肺血容量（CPBV）与总血容量（TBV）之比显著更高。去甲肾上腺素的升压剂量升高（p<0.0001），且与心输出量的基础值（p<0.005）、心肺血容量（p<0.001）和CPBV/TBV比值（p<0.01）直接相关。在持续性高血压受试者中未观察到这些结果：唯一显著的结果是去甲肾上腺素的升压剂量与基础舒张动脉压之间呈负相关（p<0.0001）。本研究提供了证据，表明临界高血压受试者的心输出量升高与静脉回流增加和交感神经静脉张力增强有关。
