阿替洛尔对不稳定型高血压的血流动力学影响。

Hemodynamic effects of atenolol in labile hypertension.

作者信息

González-Gómez A, García-Barreto D, Fránquiz J M

出版信息

Arch Int Pharmacodyn Ther. 1983 Feb;261(2):260-7.

Abstract

The hemodynamic effects provoked by 15 days treatment with atenolol 100 mg/day in a single oral dose were studied in labile hypertensive patients. Radiocardiography with 131IRHISA was employed in order to calculate: Cardiac output and index (CO, CI); stroke volume and index (SV, SI), total blood volume and index (TBV, TBVI) and total peripheral resistance (TPR). Atenolol caused a significant reduction in arterial pressure, heart rate, CO and CI (p less than 0.001). The drug also reduced TBV (11%) and TBVI (16%) from controls: however, these changes were not significant. A direct relationship was found between CO with heart rate (r = 0.79, p less than 0.01), and between CO with TBV (r = 0.82, p less than 0.01); also an inverse relationship was found between TBV with TPR (r = 0.874, p less than 0.01). These relationships lost significance during treatment with the drug. The lowering of cardiac output contributes to the anti-hypertensive effect of atenolol, but although the reduction in blood volume was not significant it is possible that this also may be a factor.

摘要

在不稳定型高血压患者中，研究了每日单次口服100毫克阿替洛尔，连续治疗15天所引发的血流动力学效应。采用131I标记人血清白蛋白的放射性心动图来计算：心输出量及心指数（CO，CI）；每搏输出量及每搏指数（SV，SI），总血容量及总血容量指数（TBV，TBVI）以及总外周阻力（TPR）。阿替洛尔可使动脉压、心率、CO及CI显著降低（p<0.001）。该药物还使TBV较对照组降低了11%，TBVI降低了16%；然而，这些变化并不显著。发现CO与心率之间存在直接关系（r = 0.79，p<0.01），CO与TBV之间也存在直接关系（r = 0.82，p<0.01）；此外，还发现TBV与TPR之间存在负相关关系（r = 0.874，p<0.01）。在药物治疗期间，这些关系失去了显著性。心输出量的降低有助于阿替洛尔的降压作用，尽管血容量的减少并不显著，但这也可能是一个因素。