Jones S A, Horiuchi S, Topley N, Yamamoto N, Fuller G M
Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3US, Wales, UK.
FASEB J. 2001 Jan;15(1):43-58. doi: 10.1096/fj.99-1003rev.
Interleukin 6 (IL-6) performs a prominent role during disease and has been described as both a pro- and anti-inflammatory cytokine. A key feature in the regulation of IL-6 responses has been the identification of a soluble interleukin 6 receptor (sIL-6R), which forms a ligand-receptor complex with IL-6 that is capable of stimulating a variety of cellular responses including proliferation, differentiation and activation of inflammatory processes. Elevated sIL-6R levels have been documented in numerous clinical conditions indicating that its production is coordinated as part of a disease response. Thus, sIL-6R has the potential to regulate both local and systemic IL-6-mediated events. This review will outline the central role of sIL-6R in the coordination of IL-6 responses. Details relating to the mechanisms of sIL-6R production will be provided, while the potential significance of sIL-6R during the development of clinical conditions will be emphasized. We want to convey, therefore, that when thinking about the inflammatory capability of IL-6, it is essential to consider not only the action of IL-6 itself, but also the effect sIL-6R may have on cellular processes.
白细胞介素6（IL-6）在疾病过程中发挥着重要作用，被描述为一种促炎和抗炎细胞因子。白细胞介素6反应调节的一个关键特征是可溶性白细胞介素6受体（sIL-6R）的发现，它与IL-6形成配体-受体复合物，能够刺激多种细胞反应，包括增殖、分化和炎症过程的激活。在许多临床情况下都记录到sIL-6R水平升高，这表明其产生是作为疾病反应的一部分而协调进行的。因此，sIL-6R有可能调节局部和全身IL-6介导的事件。本综述将概述sIL-6R在协调IL-6反应中的核心作用。将提供与sIL-6R产生机制相关的详细信息，同时强调sIL-6R在临床疾病发展过程中的潜在意义。因此，我们想要传达的是，在考虑IL-6的炎症能力时，不仅要考虑IL-6本身的作用，还要考虑sIL-6R可能对细胞过程产生的影响。
