Arai Y, Yamazaki M, Mori O, Muramatsu H, Asano G, Katayama Y
The Second Department of Internal Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, 113-8602, Tokyo, Japan.
Brain Res. 2001 Jan 12;888(2):287-296. doi: 10.1016/s0006-8993(00)03082-1.
Alzheimer's disease (AD) and Parkinson's disease share common clinical and pathological features. In this study, we examined the relationship between AD pathology and alpha-synuclein aggregation. The frequency and distribution of alpha-synuclein-positive structures were systematically investigated in 27 cases with sporadic AD by alpha-synuclein immuno-histochemistry. Thirteen (48.2%) of 27 cases had various alpha-synuclein-positive structures as well as Lewy bodies. The frequency and density of senile plaques and neurofibrillary tangles were not significantly different between cases with alpha-synuclein structures and those without. alpha-Synuclein-positive structures were found most frequently in the amygdala. The alpha-synuclein-positive inclusions that are different from Lewy bodies were observed at the highest rate in the hippocampus. The discovery of alpha-synuclein as the constituent of Lewy bodies facilitated the detection of Lewy-related structures even in AD cases with widespread and numerous neurofibrillary tangles. alpha-Synuclein-positive inclusions except for Lewy bodies are exposed, and the distribution of them indicates that Lewy body formation may be influenced by the degree of tau aggregation. This study also supports the suggestion that cases with AD pathology can be classified into two groups according to the existence or absence of alpha-synuclein aggregation.
阿尔茨海默病（AD）和帕金森病具有共同的临床和病理特征。在本研究中，我们研究了AD病理学与α-突触核蛋白聚集之间的关系。通过α-突触核蛋白免疫组织化学方法，对27例散发性AD患者的α-突触核蛋白阳性结构的频率和分布进行了系统研究。27例患者中有13例（48.2%）既有各种α-突触核蛋白阳性结构，也有路易小体。有α-突触核蛋白结构的病例与无该结构的病例相比，老年斑和神经原纤维缠结的频率和密度无显著差异。α-突触核蛋白阳性结构最常见于杏仁核。在海马中观察到与路易小体不同的α-突触核蛋白阳性包涵体的比例最高。α-突触核蛋白作为路易小体的组成成分被发现，这使得即使在有广泛且大量神经原纤维缠结的AD病例中，也能检测到与路易小体相关的结构。除路易小体外的α-突触核蛋白阳性包涵体被发现，其分布表明路易小体的形成可能受tau蛋白聚集程度的影响。本研究还支持这样的观点，即根据α-突触核蛋白聚集的有无，AD病理学病例可分为两组。
