Torrón C, Ferrer E, Ruiz-Moreno O, Cuevas R, Pérez S, Alabart J L, Honrubia F M
Servicio de Oftalmología, Hospital Miguel Servet, Diputación General de Aragón, Zaragoza, España.
Arch Soc Esp Oftalmol. 2000 Jun;75(6):377-82.
To study the antiinflammatory effect of topical pranoprofen on the lipoxygenase metabolism of the arachidonic acid in albino rabbits.
Endotoxin-induced uveitis (EIU) was produced in albino rabbits by intravitreal injection in the right eye with 10 microg of Salmonella typhymurium lipopolysacharide A in 5 microl saline solution. We have used 5 groups of 12 animals each. Control group (G-I) was injected with 5 microl of saline solution and 5 microl of ET solution were injected in the remaining groups. Groups III, IV and V were treated with topical pranoprofen 2 hours before intravitreal injection, immediately after and every 6, 4 and 2 hours respectively. The animals were sacrificed 24 hours after the ET administration. Cellular and B4 leukotrien concentration in the aqueous humour was determined.
The groups treated with pranoprofen showed a significant decrease in the cellular concentration in relation to the group of endotoxin (G-II). We did not observe any difference in the B4 leukotriene concentration between ET group and topical pranoprofen groups.
Topical pranoprofen has not increased the lipoxygenase metabolism of the arachidonic acid.
研究局部应用普拉洛芬对白化兔花生四烯酸脂氧合酶代谢的抗炎作用。
通过向白化兔右眼玻璃体内注射10微克鼠伤寒沙门氏菌脂多糖A溶于5微升盐溶液中诱导内毒素性葡萄膜炎（EIU）。我们使用了5组，每组12只动物。对照组（G-I）注射5微升盐溶液，其余组注射5微升ET溶液。第三、四、五组在玻璃体内注射前2小时、注射后立即以及分别每6小时、4小时和2小时局部应用普拉洛芬。在给予ET后24小时处死动物。测定房水中细胞和B4白三烯浓度。
与内毒素组（G-II）相比，用普拉洛芬治疗的组细胞浓度显著降低。我们未观察到ET组与局部应用普拉洛芬组之间B4白三烯浓度有任何差异。
局部应用普拉洛芬未增加花生四烯酸的脂氧合酶代谢。
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