Levels of prostaglandins F-2alpha and E-2 in human endometrium during the menstrual cycle.

A comparison between the prostaglandins found in proliferative and secretory endometrium in normal and tumor-bearing tissues is reported. The content of prostaglandins F-2alpha and E-2 is related to the three phases of the menstrual cycle and correlates with cyclic ovarian hormone variations. The menstrual phase is characterized by a high content of PGF-2alpha. High prostaglandin levels are found in tissues from patients with pathologic diseases such as adenocarcinoma of the endometrium when compared to normal tissues.