Alam M, Jogee M, MacGregor W G, Dowdell J W, Elder M G, Myatt L
Br J Cancer. 1982 Mar;45(3):384-9. doi: 10.1038/bjc.1982.65.
Peripheral plasma levels of immunoreactive 6-oxo-PGF1 alpha, the stable hydrolysis product of prostacyclin, were significantly higher in female patients with tumours of the genital tract than in normal controls. In the groups with malignant tumours, these high levels declined after operation and/or radiotherapy if the tumour responded to treatment. In patients who did not respond to treatment or with tumour recurrence, levels of plasma 6-oxo-PGF1 alpha remained high or even rose further. Benign gynaecological tumours were also associated with significantly raised plasma 6-oxo-PGF1 alpha levels, and these fell to normal levels immediately on surgical removal of the tumour. Possible reasons for these alterations are described. Further investigations are warranted to see whether serial measurements of plasma 6-oxo-PGF1 alpha could be used as a prognostic index for the clinical status of patients with gynaecological tumours.
前列环素的稳定水解产物——免疫反应性6-氧代-前列腺素F1α的外周血浆水平，在患有生殖道肿瘤的女性患者中显著高于正常对照组。在患有恶性肿瘤的组中，如果肿瘤对治疗有反应，这些高水平在手术和/或放疗后会下降。在对治疗无反应或肿瘤复发的患者中，血浆6-氧代-前列腺素F1α水平保持高值甚至进一步升高。良性妇科肿瘤也与血浆6-氧代-前列腺素F1α水平显著升高有关，并且在肿瘤手术切除后这些水平立即降至正常。文中描述了这些变化的可能原因。有必要进一步研究，以确定血浆6-氧代-前列腺素F1α的系列测量是否可作为妇科肿瘤患者临床状况的预后指标。
