CD1分子对自身及微生物脂质的呈递

Presentation of self and microbial lipids by CD1 molecules.

作者信息

Matsuda J L, Kronenberg M

机构信息

Department of Biology, University of California at San Diego, 92121, USA.

出版信息

Curr Opin Immunol. 2001 Feb;13(1):19-25. doi: 10.1016/s0952-7915(00)00176-x.

DOI:10.1016/s0952-7915(00)00176-x

PMID:11154912

Abstract

CD1 molecules present both self lipids and microbial lipids. Recent studies have elucidated novel antigenic structures that can be presented by CD1 for T cell stimulation, as well as new pathways for lipid-antigen presentation. Additionally, the development of lipid-CD1 tetramers now permits the tracking of CD1-reactive T cells during immune responses. Despite this, the roles of CD1-reactive T cells in both host defense and immune regulation remain to be unequivocally defined.

摘要

CD1分子可呈递自身脂质和微生物脂质。最近的研究阐明了可由CD1呈递以刺激T细胞的新型抗原结构，以及脂质抗原呈递的新途径。此外，脂质-CD1四聚体的研发使得在免疫反应期间能够追踪CD1反应性T细胞。尽管如此，CD1反应性T细胞在宿主防御和免疫调节中的作用仍有待明确界定。