Champagne Eric, Martinez Laurent O, Vantourout Pierre, Collet Xavier, Barbaras Ronald
Université Paul Sabatier, Centre de Physiopathologie de Toulouse Purpan, Departement Lipoproteines et Médiateurs Lipidiques, Toulouse, France.
Immunol Res. 2005;33(3):241-55. doi: 10.1385/ir:33:3:241.
Recent findings reveal unanticipated connections between the fields of lipid metabolism and immunology. They concern gammadelta and NKT cells, nonconventional T cell populations that do not recognize protein antigens and are involved in immunity against cancer, defense against infections, or in regulation of classical immune responses. In this review, we summarize data linking perturbations of apolipoprotein levels and nonconventional T cells with inflammatory processes such as autoimmune diseases or atherosclerosis. We integrate and discuss recent findings on the implication of apolipoproteins in antigen recognition by gammadelta and NKT cells, with emphasis on apolipoproteins A-I and E. These findings also provide indications that apolipoproteins influence antitumor immunosurveillance.
最近的研究结果揭示了脂质代谢和免疫学领域之间意想不到的联系。这些联系涉及γδ和NKT细胞，它们是非传统的T细胞群体，不识别蛋白质抗原，参与抗癌免疫、抗感染防御或经典免疫反应的调节。在这篇综述中，我们总结了将载脂蛋白水平的扰动和非传统T细胞与自身免疫性疾病或动脉粥样硬化等炎症过程联系起来的数据。我们整合并讨论了关于载脂蛋白在γδ和NKT细胞抗原识别中的作用的最新发现，重点是载脂蛋白A-I和E。这些发现还表明载脂蛋白会影响抗肿瘤免疫监视。
