Horne M K, Rosse W F, Flickinger E G, Saltzman H A
Blood. 1975 Mar;45(3):365-75.
The "early-labeled" peak (ELP) of 14CO excretion following injection of glycine-2-14C was used to study erythropoiesis in a patient with sideroblastic anemia and in four subjects with myeloproliferative disorders. The ELP was greatly enlarged in all patients, as compared with a normal volunteer. The contour of the peaks from the hematologically abnormal subjects suggested the presence of increased erythroid heme degradation. In the patient with sideroblastic anemia, all hours of the early peak were significantly reduced after transfusion. This was interpreted to mean that even the earliest or "nonerythroid" phase of the peak is influenced by erythropoietic activity, at least under conditions of erythropoietic stress.
注射甘氨酸 -2-¹⁴C 后¹⁴CO 排泄的“早期标记”峰（ELP）被用于研究一名铁粒幼细胞贫血患者和四名骨髓增殖性疾病患者的红细胞生成情况。与一名正常志愿者相比，所有患者的 ELP 均显著增大。血液学异常受试者的峰轮廓表明存在红细胞血红素降解增加的情况。在铁粒幼细胞贫血患者中，输血后早期峰的所有时段均显著降低。这被解释为意味着即使是该峰的最早或“非红细胞生成”阶段也受到红细胞生成活性的影响，至少在红细胞生成应激的情况下是如此。
