Khodorov B I, Voronovitskii E G, Ignat'eva V B
Bull Exp Biol Med. 1975 Jan;77(7):741-4. doi: 10.1007/BF00799305.
The local anaphylactic reaction and the effects of histamine during blocking of the slow sodium-calcium channels by isoptine were investigated in the spontaneously contracting oracle of the atrium of a guinea pig previously sensitized to egg albumin. Simultaneously with the intracellular recording of the potentials, isometric contractions of the preparation were recorded by means of a mechanotron. The investigation showed that egg albumin (0.2 mg/ml) and histamine (0.1 mg/ml) are antagonists of isoptine (2-16 mg/liter) as regards its effect on automatic contraction and duration of the action potential. It is postulated that this anaphylatic reaction is based on activation of the slow sodium-calcium channels in the surface membrane of the myocardial fibers.
在先前对卵清蛋白致敏的豚鼠心房自发收缩标本中，研究了异搏定阻断慢钠钙通道期间的局部过敏反应和组胺的作用。在进行细胞内电位记录的同时，用机械传感器记录标本的等长收缩。研究表明，就其对自动收缩和动作电位持续时间的影响而言，卵清蛋白（0.2毫克/毫升）和组胺（0.1毫克/毫升）是异搏定（2 - 16毫克/升）的拮抗剂。据推测，这种过敏反应是基于心肌纤维表面膜中慢钠钙通道的激活。
