慢反应物质A参与豚鼠小肠的舒尔茨-戴尔反应。
Involvement of SRS-A in the Schultz-Dale response of the guinea-pig small intestine.
作者信息
Herman A G, Laekeman G M, van Beek H A
出版信息
Br J Pharmacol. 1979 Jul;66(3):385-9. doi: 10.1111/j.1476-5381.1979.tb10842.x.
Abstract
1 The anaphylactic reaction of the guinea-pig ileum, the so called Schultz-Dale reaction, shows a biphasic response: a short rapid contraction followed by a partial relaxation and a slow contractile response. 2 Dose-response curves with ovalbumin as an antigen were obtained for the quick and slow contraction of this anaphylactic reaction. 3 Mepyramine (1 microgram/ml) blocked the rapid first contraction, but failed to abolish the slow one in about 50% of the animals studied. 4 The SRS-A antagonist, FPL 55712, significantly depressed the slow sustained contraction during the Schultz-Dale reaction. Disodiumcromoglycate was without effect on both phases when it was added 5 min before addition of the antigen. However, when added simultaneously with the antigen it produced a 30% suppression of the slow phase in the highest concentration used.
摘要
- 豚鼠回肠的过敏反应，即所谓的舒尔茨 - 戴尔反应，呈现双相反应：先是短暂快速收缩，随后部分松弛，接着是缓慢的收缩反应。2. 以卵清蛋白作为抗原，获得了该过敏反应快速和缓慢收缩的剂量 - 反应曲线。3. 美吡拉敏（1微克/毫升）阻断了快速的首次收缩，但在所研究的约50%的动物中未能消除缓慢收缩。4. SRS - A拮抗剂FPL 55712在舒尔茨 - 戴尔反应期间显著抑制了缓慢的持续收缩。色甘酸钠在添加抗原前5分钟加入时，对两个阶段均无作用。然而，当与抗原同时添加时，在所用最高浓度下它对缓慢阶段产生了30%的抑制作用。
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本文引用的文献
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The release of histamine and formation of a slow-reacting substance (SRS-A) during anaphylactic shock.过敏性休克期间组胺的释放及慢反应物质（SRS-A）的形成。
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Disodium cromoglycate (FPL 670) ('Intal'): a specific inhibitor of reaginic antibody-antigen mechanisms.色甘酸钠（FPL 670）（“因他舒”）：一种反应素抗体-抗原机制的特异性抑制剂。
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Growth hormone and premature ageing.生长激素与早衰
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Role of histamine, substance P and slow-reacting substance of anaphylaxis (SRS-A) in the Schultz-Dale reaction of the guinea-pig ileum.组胺、P物质和过敏反应慢反应物质（SRS-A）在豚鼠回肠舒尔茨-戴尔反应中的作用。
Arch Int Physiol Biochim. 1968 Apr;76(2):344-62. doi: 10.3109/13813456809058711.
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Release of prostaglandins, a prostaglandin metabolite, slow-reacting substance and histamine from anaphylactic lungs, and its modification by catecholamines.前列腺素、一种前列腺素代谢产物、慢反应物质和组胺从过敏性肺组织中的释放，以及儿茶酚胺对其的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1974;284(3):279-93. doi: 10.1007/BF00500347.
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