Pérez-Yarza E G, Múgica J, Zabaleta M, Guedea C, Tabuenca J M
An Esp Pediatr. 1979 May;12(5):411-8.
Authors report 49 patients bacteriologicallyly diagnosed of acute meningococcal infection collected during a 12 months period out of a series of 76 cases diagnosed on clinical grounds. "N. meningitidis" was found in 18 blood and 43 CSF cultures. 31 cases were of the B-group, one was A-group and 17 were not typed. All of them were sulphamide resistant. Hyperthermia with vomiting, cephalea, arthralgia and seizures were the initial symptoms. All patients showed pettechiae, purpura and/or ecchymoses. Endotoxic shock was diagnosed in 26,5% of the cases. In them systolic blood pressures were under p-5. Overall mortality was 14%, and that of endotoxic patients 53%. Therapeutic routines and chemoprophylaxis are reviewed.
作者报告了在12个月期间从76例临床诊断病例中细菌学确诊的49例急性脑膜炎球菌感染患者。在18份血液培养物和43份脑脊液培养物中发现了“脑膜炎奈瑟菌”。31例为B组，1例为A组，17例未分型。所有菌株均对磺胺耐药。高热伴呕吐、头痛、关节痛和癫痫发作是初始症状。所有患者均出现瘀点、紫癜和/或瘀斑。26.5%的病例诊断为内毒素休克。这些患者的收缩压低于第5百分位数。总体死亡率为14%，内毒素血症患者的死亡率为53%。对治疗方案和化学预防进行了综述。
