Ursua M I, Rodríguez-Mayo M, Fernández-Quintairos J, Domínguez D, Luaces J, Agulla A
Servicio de Microbiología, Complejo Hospitalario Arquitecto Marcide-Profesor Novoa Santos, Ferrol, La Coruña.
Enferm Infecc Microbiol Clin. 1997 Aug-Sep;15(7):369-72.
In recent years an increase has been observed in the prevalence of meningococcal infection by Neisseria meningitidis serogroup C and in the appearance of strains with moderate resistance to penicillin.
A microbiologic study of the cases of meningococcal infection of serogroup C treated from 1995 to 1996 in the health care area of Ferrol (La Coruña, Spain) was carried out.
Twenty-nine cases were detected in 1995 and 28 in 1996. Meningococcal infection was observed in patients ranging from 8 months to 21 years of age (mean 5.7 years). Distribution by sex was homogeneous. Two patients died. According to the clinical presentation, 11 were sepsis (38%), 4 meningitis (14%) and 14 both processes (48%). In 4 LCR samples, the analytical study was normal with posterior positive culture results. The detection of bacterial antigen by latex agglutination in CSF only detected 32% of the cases. MIC study determined that 11 strains (38%) presented moderate resistance to penicillin, 9 with a MIC of 0.12 microgram/ml, one with a MIC of 0.25 microgram/ml and another with a MIC of 0.5 microgram/ml. In all the cases the strains were sensitive to cefotaxime (MIC < or = 0.06 microgram/ml) and rifampicin (MIC < or = 0.5 microgram/ml). All the strains belonged to serogroup C serotype 2b, serosubtype P1.2,5. During the study period 4 additional cases of meningococcal disease by serogroup B were observed.
近年来，已观察到C群脑膜炎奈瑟菌引起的脑膜炎球菌感染患病率有所上升，并且出现了对青霉素具有中度耐药性的菌株。
对1995年至1996年在费罗尔（西班牙拉科鲁尼亚）医疗保健区治疗的C群脑膜炎球菌感染病例进行了微生物学研究。
1995年检测到29例，1996年检测到28例。脑膜炎球菌感染见于8个月至21岁的患者（平均5.7岁）。性别分布均匀。2例患者死亡。根据临床表现，11例为败血症（38%），4例为脑膜炎（14%），14例两者皆有（48%）。在4份乳胶凝集反应（LCR）样本中，分析研究结果正常，但随后培养结果呈阳性。脑脊液中通过乳胶凝集法检测细菌抗原仅检测出32%的病例。最低抑菌浓度（MIC）研究确定，11株菌株（38%）对青霉素呈现中度耐药性，9株的MIC为0.12微克/毫升，1株的MIC为0.25微克/毫升，另一株的MIC为0.5微克/毫升。所有病例中的菌株对头孢噻肟（MIC≤0.06微克/毫升）和利福平（MIC≤0.5微克/毫升）敏感。所有菌株均属于C群2b血清型、P1.2,5血清亚型。在研究期间，还观察到另外4例B群脑膜炎球菌病病例。
