InterPro——蛋白质家族、结构域和功能位点的综合文档资源。

InterPro--an integrated documentation resource for protein families, domains and functional sites.

作者信息

Apweiler R, Attwood T K, Bairoch A, Bateman A, Birney E, Biswas M, Bucher P, Cerutti L, Corpet F, Croning M D, Durbin R, Falquet L, Fleischmann W, Gouzy J, Hermjakob H, Hulo N, Jonassen I, Kahn D, Kanapin A, Karavidopoulou Y, Lopez R, Marx B, Mulder N J, Oinn T M, Pagni M, Servant F, Sigrist C J, Zdobnov E M

机构信息

EMBL Outstation--European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

出版信息

Bioinformatics. 2000 Dec;16(12):1145-50. doi: 10.1093/bioinformatics/16.12.1145.

DOI:10.1093/bioinformatics/16.12.1145

PMID:11159333

Abstract

MOTIVATION

InterPro is a new integrated documentation resource for protein families, domains and functional sites, developed initially as a means of rationalising the complementary efforts of the PROSITE, PRINTS, Pfam and ProDom database projects.

RESULTS

Merged annotations from PRINTS, PROSITE and Pfam form the InterPro core. Each combined InterPro entry includes functional descriptions and literature references, and links are made back to the relevant parent database(s), allowing users to see at a glance whether a particular family or domain has associated patterns, profiles, fingerprints, etc. Merged and individual entries (i.e. those that have no counterpart in the companion resources) are assigned unique accession numbers. Release 1.2 of InterPro (June 2000) contains over 3000 entries, representing families, domains, repeats and sites of post-translational modification (PTMs) encoded by 6581 different regular expressions, profiles, fingerprints and Hidden Markov Models (HMMs). Each InterPro entry lists all the matches against SWISS-PROT and TrEMBL (more than 1000000 hits from 264333 different proteins out of 384572 in SWISS-PROT and TrEMBL).

摘要

动机

InterPro是一个针对蛋白质家族、结构域和功能位点的新型综合文档资源库，最初是作为整合PROSITE、PRINTS、Pfam和ProDom数据库项目互补工作的一种手段而开发的。

结果

来自PRINTS、PROSITE和Pfam的合并注释构成了InterPro的核心。每个合并的InterPro条目都包含功能描述和文献参考，并链接回相关的父数据库，这使得用户能够一眼看出某个特定家族或结构域是否具有相关的模式、谱、指纹等。合并条目和单独条目（即在配套资源中没有对应条目的条目）都被分配了唯一的登录号。InterPro 1.2版本（2000年6月）包含3000多个条目，代表了由6581个不同的正则表达式、谱、指纹和隐马尔可夫模型（HMM）编码的家族、结构域、重复序列和翻译后修饰（PTM）位点。每个InterPro条目列出了与SWISS-PROT和TrEMBL的所有匹配项（来自SWISS-PROT和TrEMBL中384572个不同蛋白质中的264333个不同蛋白质的超过1000000次匹配）。