• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

介质在卵清蛋白致敏的棕色挪威大鼠气道中抗原诱导的支气管痉挛和微血管渗漏中的作用。

Mediator involvement in antigen-induced bronchospasm and microvascular leakage in the airways of ovalbumin sensitized Brown Norway rats.

作者信息

Hele D J, Birrell M A, Webber S E, Foster M L, Belvisi M G

机构信息

Respiratory Pharmacology Group, Department of Cardiothoracic Surgery, Imperial College School of Medicine, National Heart & Lung Institute, Dovehouse Street, Chelsea, London SW3 6LY.

出版信息

Br J Pharmacol. 2001 Jan;132(2):481-8. doi: 10.1038/sj.bjp.0703847.

DOI:10.1038/sj.bjp.0703847
PMID:11159698
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1572587/
Abstract
  1. To determine which mediators are involved in antigen-induced bronchospasm and microvascular leakage in the airways of ovalbumin sensitised Brown Norway rats we investigated the effect of a histamine H(1) receptor antagonist, mepyramine, a 5-HT receptor antagonist, methysergide, and a cys-leukotriene-1 receptor antagonist, montelukast. 2. Ovalbumin at 1 mg kg(-1) i.v. caused a significant increase in microvascular leakage in the airways and at 3 mg kg(-1) i.v. caused a significant increase in airways resistance. 3. Histamine (1 mg kg(-1) i.v.), 5-HT (0.1 mg kg(-1) i.v.) and leukotriene D(4) (LTD(4), 50 microg kg(-1) i.v.) caused a significant increase in microvascular leakage in the airways. 4. Mepyramine (1 mg kg(-1) i.v.), methysergide (0.1 mg kg(-1) i.v.), or montelukast (30 mg kg(-1) i.v.) inhibited histamine, 5-HT or LTD(4) -induced microvascular leakage respectively. 5. Methysergide (0.1 mg kg(-1) i.v.) reduced ovalbumin-induced microvascular leakage in the trachea and at 0.3 mg kg(-1) i.v. inhibited bronchospasm (38 and 58%, respectively). Montelukast (30 mg kg(-1) p.o.) reduced ovalbumin-induced microvascular leakage in airway tissue to basal levels (78%) and inhibited ovalbumin-induced bronchospasm (50%). Mepyramine (3 mg kg(-1) i.v.) had no effect on ovalbumin-induced leakage or bronchospasm. 6. A combination of all three compounds (mepyramine, methysergide and montelukast) reduced ovalbumin-induced microvascular leakage in airway tissue to basal levels (70 - 78%) and almost completely inhibited bronchospasm (92%). 7. Antigen-induced bronchospasm appears to equally involve the activation of 5-HT and cys-leukotriene-1 receptors whereas ovalbumin-induced microvascular leakage appears to be predominantly mediated by cys-leukotriene-1 receptors.
摘要
  1. 为了确定哪些介质参与卵清蛋白致敏的棕色挪威大鼠气道中抗原诱导的支气管痉挛和微血管渗漏，我们研究了组胺H(1)受体拮抗剂美吡拉敏、5-羟色胺（5-HT）受体拮抗剂麦角新碱和半胱氨酰白三烯-1受体拮抗剂孟鲁司特的作用。2. 静脉注射1mg/kg的卵清蛋白可导致气道微血管渗漏显著增加，静脉注射3mg/kg则可导致气道阻力显著增加。3. 组胺（静脉注射1mg/kg）、5-HT（静脉注射0.1mg/kg）和白三烯D4（LTD4，静脉注射50μg/kg）可导致气道微血管渗漏显著增加。4. 美吡拉敏（静脉注射1mg/kg）、麦角新碱（静脉注射0.1mg/kg）或孟鲁司特（静脉注射30mg/kg）分别抑制组胺、5-HT或LTD4诱导的微血管渗漏。5. 麦角新碱（静脉注射0.1mg/kg）可降低卵清蛋白诱导的气管微血管渗漏，静脉注射0.3mg/kg时可抑制支气管痉挛（分别为38%和58%）。孟鲁司特（口服30mg/kg）可将卵清蛋白诱导的气道组织微血管渗漏降至基础水平（78%），并抑制卵清蛋白诱导的支气管痉挛（50%）。美吡拉敏（静脉注射3mg/kg）对卵清蛋白诱导的渗漏或支气管痉挛无影响。6. 三种化合物（美吡拉敏、麦角新碱和孟鲁司特）联合使用可将卵清蛋白诱导的气道组织微血管渗漏降至基础水平（70 - 78%），并几乎完全抑制支气管痉挛（92%）。7. 抗原诱导的支气管痉挛似乎同样涉及5-HT和半胱氨酰白三烯-1受体的激活，而卵清蛋白诱导的微血管渗漏似乎主要由半胱氨酰白三烯-1受体介导。

相似文献

1
Mediator involvement in antigen-induced bronchospasm and microvascular leakage in the airways of ovalbumin sensitized Brown Norway rats.介质在卵清蛋白致敏的棕色挪威大鼠气道中抗原诱导的支气管痉挛和微血管渗漏中的作用。
Br J Pharmacol. 2001 Jan;132(2):481-8. doi: 10.1038/sj.bjp.0703847.
2
In vitro airway and tissue response to antigen in sensitized rats. Role of serotonin and leukotriene D4.致敏大鼠体外气道和组织对抗原的反应。血清素和白三烯D4的作用。
Am J Respir Crit Care Med. 1995 Jul;152(1):81-6. doi: 10.1164/ajrccm.152.1.7599867.
3
A role for histamine and substance P in immediate allergic responses in guinea pig airways: characterization of MDL 108,207DA, a dual H1/NK-1 receptor antagonist.组胺和P物质在豚鼠气道速发型过敏反应中的作用：双重H1/NK-1受体拮抗剂MDL 108,207DA的特性研究
Int Arch Allergy Immunol. 1998 Feb;115(2):169-78. doi: 10.1159/000023898.
4
Role of PAF in the late airway microvascular leakage induced by antigen in IgE-sensitized rat.血小板活化因子在IgE致敏大鼠中抗原诱导的晚期气道微血管渗漏中的作用
Fundam Clin Pharmacol. 1995;9(4):350-6. doi: 10.1111/j.1472-8206.1995.tb00509.x.
5
Pharmacological characterization of the late phase reduction in lung functions and correlations with microvascular leakage and lung edema in allergen-challenged Brown Norway rats.变应原攻击的褐家鼠肺功能后期减少的药理学特征及其与微血管渗漏和肺水肿的相关性。
Pulm Pharmacol Ther. 2013 Dec;26(6):677-84. doi: 10.1016/j.pupt.2013.03.005. Epub 2013 Mar 19.
6
Effect of theophylline administered intratracheally as a dry powder formulation on bronchospasm and airway microvascular leakage in the anesthetized guinea-pig.气管内给予干粉制剂的茶碱对麻醉豚鼠支气管痉挛和气道微血管渗漏的影响。
Pulm Pharmacol. 1994 Aug;7(4):243-9. doi: 10.1006/pulp.1994.1027.
7
Effect of a peptide leukotriene antagonist, ONO-1078 on antigen-induced airway microvascular leakage in actively sensitized guinea pigs.肽白三烯拮抗剂ONO-1078对主动致敏豚鼠抗原诱导的气道微血管渗漏的影响。
Life Sci. 1992;51(20):1577-83. doi: 10.1016/0024-3205(92)90620-5.
8
Anti-anaphylactic activity of the novel selective histamine H1 receptor antagonist mizolastine in the rodent.新型选择性组胺H1受体拮抗剂咪唑斯汀在啮齿动物中的抗过敏活性。
Arzneimittelforschung. 1995 May;45(5):559-68.
9
The effect of the selective PAF antagonist CIS-19 on PAF- and antigen-induced bronchoconstriction, microvascular leakage and bronchial hyperreactivity in guinea-pigs.选择性血小板活化因子拮抗剂CIS-19对豚鼠血小板活化因子和抗原诱导的支气管收缩、微血管渗漏及支气管高反应性的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1997 Feb;355(2):210-6. doi: 10.1007/pl00004934.
10
Characterization of neurogenic inflammation in the airways of two highly inbred rat strains.两种高度近交系大鼠气道中神经源性炎症的特征分析
Am J Respir Crit Care Med. 1995 Dec;152(6 Pt 1):1796-804. doi: 10.1164/ajrccm.152.6.8520739.

引用本文的文献

1
A current review on animal models of anti-asthmatic drugs screening.抗哮喘药物筛选动物模型的当前综述。
Front Pharmacol. 2025 Jan 28;16:1508460. doi: 10.3389/fphar.2025.1508460. eCollection 2025.
2
Characterization of Selective and Potent JAK1 Inhibitors Intended for the Inhaled Treatment of Asthma.用于哮喘吸入治疗的选择性和高效 JAK1 抑制剂的表征。
Drug Des Devel Ther. 2022 Aug 31;16:2901-2917. doi: 10.2147/DDDT.S354291. eCollection 2022.
3
Is there any effect of montelukast on prevention of myringosclerosis after myringotomy in a rat model?在大鼠模型中，孟鲁司特对鼓膜切开术后预防鼓膜硬化症有任何影响吗？
Eur Arch Otorhinolaryngol. 2019 Jan;276(1):57-62. doi: 10.1007/s00405-018-5181-3. Epub 2018 Oct 30.
4
Role of EP2 and EP4 receptors in airway microvascular leak induced by prostaglandin E2.EP2和EP4受体在前列腺素E2诱导的气道微血管渗漏中的作用。
Br J Pharmacol. 2016 Mar;173(6):992-1004. doi: 10.1111/bph.13400.
5
Cysteinyl leukotriene receptor antagonists inhibit tumor metastasis by inhibiting capillary permeability.半胱氨酰白三烯受体拮抗剂通过抑制毛细血管通透性来抑制肿瘤转移。
Keio J Med. 2010;59(1):10-8. doi: 10.2302/kjm.59.10.
6
Impact of inhaled corticosteroids and leukotriene receptor antagonists on airway remodeling.吸入性糖皮质激素和白三烯受体拮抗剂对气道重塑的影响。
Clin Rev Allergy Immunol. 2004 Aug;27(1):59-64. doi: 10.1385/CRIAI:27:1:059.
7
Bidirectional interactions between antigen-bearing respiratory tract dendritic cells (DCs) and T cells precede the late phase reaction in experimental asthma: DC activation occurs in the airway mucosa but not in the lung parenchyma.在实验性哮喘中，携带抗原的呼吸道树突状细胞（DCs）与T细胞之间的双向相互作用先于晚期反应：DC激活发生在气道黏膜而非肺实质。
J Exp Med. 2003 Jul 7;198(1):19-30. doi: 10.1084/jem.20021328. Epub 2003 Jun 30.
8
Montelukast: a review of its therapeutic potential in asthma in children 2 to 14 years of age.孟鲁司特：2至14岁儿童哮喘治疗潜力综述
Paediatr Drugs. 2002;4(2):123-39. doi: 10.2165/00128072-200204020-00005.

本文引用的文献

1
Roles of adhesion molecules ICAM-1 and alpha4 integrin in antigen-induced changes in microvascular permeability associated with lung inflammation in sensitized brown Norway rats.黏附分子细胞间黏附分子-1（ICAM-1）和α4整合素在致敏的棕色挪威大鼠抗原诱导的与肺部炎症相关的微血管通透性变化中的作用。
Am J Respir Cell Mol Biol. 1997 Dec;17(6):757-66. doi: 10.1165/ajrcmb.17.6.2697.
2
Dual action of nitric oxide on airway plasma leakage.一氧化氮对气道血浆渗漏的双重作用。
Am J Respir Crit Care Med. 1997 Mar;155(3):869-74. doi: 10.1164/ajrccm.155.3.9117019.
3
Airway and tissue behavior during early response in sensitized rats: role of 5-HT and LTD4.致敏大鼠早期反应期间的气道和组织行为：5-羟色胺和白三烯D4的作用
J Appl Physiol (1985). 1996 Feb;80(2):583-90. doi: 10.1152/jappl.1996.80.2.583.
4
Pharmacology of montelukast sodium (Singulair), a potent and selective leukotriene D4 receptor antagonist.孟鲁司特钠（顺尔宁）的药理学，一种强效且选择性的白三烯D4受体拮抗剂。
Can J Physiol Pharmacol. 1995 Feb;73(2):191-201. doi: 10.1139/y95-028.
5
Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response.白三烯可促进毛细血管后微静脉中的血浆渗漏和白细胞黏附：与急性炎症反应相关的体内效应。
Proc Natl Acad Sci U S A. 1981 Jun;78(6):3887-91. doi: 10.1073/pnas.78.6.3887.
6
Vascular protein linkage in various tissue induced by substance P, capsaicin, bradykinin, serotonin, histamine and by antigen challenge.P物质、辣椒素、缓激肽、血清素、组胺以及抗原激发在多种组织中诱导的血管蛋白连接。
Naunyn Schmiedebergs Arch Pharmacol. 1983 Nov;324(3):212-8. doi: 10.1007/BF00503897.
7
Reagin synthesis in inbred strains of rats.近交系大鼠中反应素的合成
Immunology. 1974 Aug;27(2):245-53.
8
Maximal airway narrowing to inhaled leukotriene D4 in normal subjects. Comparison and interaction with methacholine.正常受试者对吸入白三烯D4的最大气道狭窄。与乙酰甲胆碱的比较及相互作用。
Am Rev Respir Dis. 1987 Oct;136(4):979-84. doi: 10.1164/ajrccm/136.4.979.
9
Inflammatory mediators involved in antigen-induced airway microvascular leakage in guinea pigs.参与豚鼠抗原诱导气道微血管渗漏的炎症介质。
Am Rev Respir Dis. 1988 Aug;138(2):395-9. doi: 10.1164/ajrccm/138.2.395.
10
Regional and time-dependent effects of inflammatory mediators on airway microvascular permeability in the guinea pig.炎症介质对豚鼠气道微血管通透性的区域和时间依赖性影响。
Clin Sci (Lond). 1989 May;76(5):479-85. doi: 10.1042/cs0760479.