TFE，一种嗜热自养甲烷杆菌中的古细菌转录因子，与真核生物转录因子TFIIEα相关。
TFE, an archaeal transcription factor in Methanobacterium thermoautotrophicum related to eucaryal transcription factor TFIIEalpha.
作者信息
Hanzelka B L, Darcy T J, Reeve J N
机构信息
Department of Microbiology, The Ohio State University, Columbus, Ohio 43210, USA.
出版信息
J Bacteriol. 2001 Mar;183(5):1813-8. doi: 10.1128/JB.183.5.1813-1818.2001.
Abstract
In the archaeon Methanobacterium thermoautotrophicum, MTH1669 encodes a protein with a sequence related to the N-terminal sequences of the alpha-subunits of eucaryal general transcription factor TFIIE. The recombinant MTH1669 gene product has been purified and shown to stimulate transcription in vitro from M. thermoautotrophicum promoters that were almost inactive or much less active in reaction mixtures that contained only M. thermoautotrophicum RNA polymerase, TATA-binding protein and transcription factor B. As all complete archaeal genome sequences contain an MTH1669 homolog, the protein encoded by this gene is apparently the first characterized example of a transcription activator, here designated TFE, that may be universally present in the Archaea.
摘要
在嗜热自养甲烷杆菌中，MTH1669编码一种蛋白质，其序列与真核生物通用转录因子TFIIE的α亚基的N端序列相关。重组MTH1669基因产物已被纯化，并显示在体外能刺激嗜热自养甲烷杆菌启动子的转录，这些启动子在仅含有嗜热自养甲烷杆菌RNA聚合酶、TATA结合蛋白和转录因子B的反应混合物中几乎没有活性或活性很低。由于所有完整的古菌基因组序列都包含一个MTH1669同源物，该基因编码的蛋白质显然是第一个被表征的转录激活因子的例子，这里命名为TFE，它可能普遍存在于古菌中。
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