哌拉西林与羧苄西林、替卡西林、氨苄西林、头孢噻吩及头孢孟多对铜绿假单胞菌和肠杆菌科细菌的体外活性比较
In vitro activity of piperacillin compared with that of carbenicillin, ticarcillin, ampicillin, cephalothin, and cefamandole against Pseudomonas aeruginosa and Enterobacteriaceae.
作者信息
Shah P P, Briedis D J, Robson H G, Conterato J P
出版信息
Antimicrob Agents Chemother. 1979 Mar;15(3):346-50. doi: 10.1128/AAC.15.3.346.
Abstract
Piperacillin (T-1220), a semisynthetic derivative of aminobenzylpenicillin, was more active than either carbenicillin or ticarcillin against Pseudomonas aeruginosa; over 60% of isolates were inhibited at a concentration of 6.3 mug/ml. Piperacillin was bactericidal for 84% of Pseudomonas strains at 100 mug/ml, carbenicillin killed 60%, and ticarcillin killed 68% at that concentration. Piperacillin was also more active than the other penicillins against isolates of Escherichia coli, Enterobacter, and Proteus mirabilis. The combination of piperacillin and tobramycin, demonstrating synergistic inhibition of 87% of strains of P. aeruginosa, was the most active of the penicillin-aminoglycoside combinations tested for synergism.
摘要
哌拉西林（T - 1220）是氨基苄青霉素的半合成衍生物，对铜绿假单胞菌的活性比羧苄西林或替卡西林更强；超过60%的分离菌株在浓度为6.3微克/毫升时受到抑制。在100微克/毫升浓度下，哌拉西林对84%的假单胞菌菌株具有杀菌作用，羧苄西林在该浓度下杀死60%，替卡西林杀死68%。哌拉西林对大肠杆菌、肠杆菌和奇异变形杆菌分离株的活性也比其他青霉素更强。哌拉西林与妥布霉素的组合对87%的铜绿假单胞菌菌株表现出协同抑制作用，是所测试的用于协同作用的青霉素 - 氨基糖苷类组合中活性最强的。
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Pseudomonas bacteremia. Review of 108 cases.假单胞菌血症。108例病例回顾。
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