Kaufman J M, Siegel N J, Hayslett J P
Circ Res. 1975 Feb;36(2):286-93. doi: 10.1161/01.res.36.2.286.
Removal of renal tissue stimulates functional and anatomical adaptation in the remaining renal parenchyma. Since recent studies have demonstrated no apparent limitation in compensatory growth following progressive surgical ablation, experiments were performed to determine the changes in glomerular filtration rate and renal blood flow. After removal of 50% of the renal mass mean nephron glomerular filtration rate increased 60%, and after ablation of 75% of the renal tissue it increased 150%. These changes paralleled the increases in renal growth under the same conditions. In comparison, mean glomerular blood flow rose 90% and 240% after 50% and 75% nephrectomy, respectively; these changes in relation to the changes in glomerular filtration rate resulted in a progressive fall in the filtration fraction. Intrarenal blood flow distribution was examined with labeled microspheres. The marked increase in renal blood flow after surgical ablation was characterized by a disproportionate rise in blood flow to the inner cortex. The present investigation, therefore, described the remarkable functional changes that occur as overall glomerular filtration rate declines and provides further insight into the mechanism responsible for maintaining water and electrolyte homeostasis after loss of functioning renal mass.
切除肾组织可刺激剩余肾实质发生功能和解剖学适应。由于最近的研究表明，在进行性手术切除后，代偿性生长没有明显限制，因此进行了实验以确定肾小球滤过率和肾血流量的变化。切除50%的肾组织后，平均单个肾单位肾小球滤过率增加了60%，切除75%的肾组织后，该滤过率增加了150%。这些变化与相同条件下肾脏生长的增加情况平行。相比之下，在切除50%和75%的肾组织后，平均肾小球血流量分别增加了90%和240%；这些与肾小球滤过率变化相关的改变导致滤过分数逐渐下降。用标记微球检查肾内血流分布。手术切除后肾血流量的显著增加表现为流向肾内皮质的血流量不成比例地增加。因此，本研究描述了随着总体肾小球滤过率下降而发生的显著功能变化，并进一步深入了解了在功能性肾组织丧失后维持水和电解质稳态的机制。
