Astoin M, Altman J
C R Seances Soc Biol Fil. 1976;170(4):734-8.
Instantaneous measurements of renal blood flow (RBF) and glomerular filtration rate (GFR) have been performed in anesthetized dogs to determine if removal of one kidney induces early functional adaptation in the remaining kidney. Increases in RBF (10%) and GFR (20%) were observed within the first minutes after exclusion of controlateral kidney; these are the earliest events described until now. These observations favour the concept that a functional adjustement may contribute to development of compensatory renal hypertrophy.
为了确定摘除一侧肾脏是否会在剩余肾脏中引发早期功能适应,已对麻醉的狗进行了肾血流量(RBF)和肾小球滤过率(GFR)的即时测量。在摘除对侧肾脏后的最初几分钟内,观察到RBF增加了10%,GFR增加了20%;这些是迄今为止所描述的最早事件。这些观察结果支持这样一种观点,即功能调节可能有助于代偿性肾肥大的发展。