Johnson D H, Rosenthal A, Nadas A S
Circulation. 1975 Apr;51(4):581-8. doi: 10.1161/01.cir.51.4.581.
A retrospective review of 149 episodes of bacterial endocarditis (BE) in 141 patients under 25 years of age, at The Children's Hospital Medical Center from 1933 through June of 1972, demonstrates increasing survival and a distinct change in the frequency of underlying congenital heart disease and rheumatic heart disease (RHD). Certain forms of congenital heart disease such as tetralogy of Fallot, small ventricular septal defect, and aortic stenosis are at particular risk for BE. Following BE, patients with ventricular septal defect and tetralogy of Fallot have less morbidity and higher survival rates than children with aortic outflow lesions. over the entire time period, alpha Streptococcus is the most common pathogen and Staphylococcus aureus, second most frequent organism. Surgical correction in patients with congenital heart disease may offer the best form of prevention.
对1933年至1972年6月期间在儿童医院医疗中心就诊的141例25岁以下患者的149例细菌性心内膜炎（BE）病例进行回顾性研究，结果显示生存率有所提高，且潜在先天性心脏病和风湿性心脏病（RHD）的发病频率发生了明显变化。某些形式的先天性心脏病，如法洛四联症、小型室间隔缺损和主动脉狭窄，患BE的风险尤其高。BE发生后，室间隔缺损和法洛四联症患者的发病率低于主动脉流出道病变患儿，生存率更高。在整个时间段内，α链球菌是最常见的病原体，金黄色葡萄球菌是第二常见的病原体。先天性心脏病患者的手术矫正可能是最佳的预防方式。
