Rakotonirina V S, Bum E N, Rakotonirina A, Bopelet M
Laboratory of Animal Physiology, Faculty of Sciences, University of Yaoundé I, B.P. 812 Yaoundé, Cameroon
Fitoterapia. 2001 Jan;72(1):22-9. doi: 10.1016/s0367-326x(00)00243-4.
The decoction of the rhizome of Cyperus articulatus is empirically used in several African countries in the treatment of a wide variety of human diseases. Studies were conducted in mice in order to determine scientifically the pharmacological properties of this medicinal herb. At the same time, the qualitative chemical characterisation of the total extract showed that C. articulatus contains flavonoids, saponins, tannins, terpenes and sugars. The total extract of the rhizome of C. articulatus does not appear to possess either anaesthetic or paralysing effects. In contrast, spontaneous motor activity is significantly reduced by the extract. However, when compared to diazepam, C. articulatus does not seem to have muscle relaxant effects. When associated with sodium thiopental or diazepam, the total extract facilitates sleep induction, and increases the total sleep time without any concomitant analgesic effect. These observations suggest that the rhizome of C. articulatus has pharmacological properties similar to those of sedatives. The sedative actions probably explain at least part of the therapeutic efficiency claimed for this plant in traditional medicine.
在几个非洲国家，人们凭经验使用节根莎草的煎剂来治疗多种人类疾病。为了科学地确定这种草药的药理特性，研究人员在小鼠身上进行了实验。与此同时，对总提取物的定性化学表征表明，节根莎草含有黄酮类化合物、皂苷、单宁、萜类化合物和糖类。节根莎草的总提取物似乎没有麻醉或麻痹作用。相反，提取物会显著降低自发运动活性。然而，与地西泮相比，节根莎草似乎没有肌肉松弛作用。当与硫喷妥钠或地西泮联合使用时，总提取物有助于诱导睡眠，并增加总睡眠时间，且没有任何伴随的镇痛作用。这些观察结果表明，节根莎草具有与镇静剂相似的药理特性。镇静作用可能至少部分解释了这种植物在传统医学中所宣称的治疗效果。
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