在被动膝关节运动期间，使用近红外地形图对镇静新生儿进行大脑功能成像。
Functional imaging of the brain in sedated newborn infants using near infrared topography during passive knee movement.
作者信息
Isobe K, Kusaka T, Nagano K, Okubo K, Yasuda S, Kondo M, Itoh S, Onishi S
机构信息
Department of Pediatrics, Kagawa Medical University, 1750-1 Mikicho, Kitagun, 761-0793, Kagawa, Japan.
出版信息
Neurosci Lett. 2001 Feb 23;299(3):221-4. doi: 10.1016/s0304-3940(01)01518-x.
Near infrared topography was used for functional imaging of the sensorimotor cortex of newborn infants during passive knee movement under sedated sleep. Contralateral knee movement caused a marked increase in oxyhemoglobin and total hemoglobin from the baseline values at almost all locations in the primary sensorimotor area of all neonates and a decrease in local deoxyhemoglobin in six of seven neonates. During ipsilateral knee movement, oxyhemoglobin and total hemoglobin showed slighter changes at a few locations, equal to 30% (mean) and 29% (mean) of the changes that occurred with contralateral stimulation, respectively. The mean times corresponding to maximal changes were 11.9 s for oxyhemoglobin and 19.1 s for deoxyhemoglobin, demonstrating that oxyhemoglobin has a much faster response than does deoxyhemoglobin.
在镇静睡眠状态下，对新生儿进行被动膝关节运动时，采用近红外地形图对其感觉运动皮层进行功能成像。对侧膝关节运动导致所有新生儿初级感觉运动区几乎所有位置的氧合血红蛋白和总血红蛋白相对于基线值显著增加，并且在7名新生儿中的6名中，局部脱氧血红蛋白减少。同侧膝关节运动期间，氧合血红蛋白和总血红蛋白在少数位置变化较小，分别相当于对侧刺激时变化的30%（平均值）和29%（平均值）。氧合血红蛋白和脱氧血红蛋白达到最大变化的平均时间分别为11.9秒和19.1秒，表明氧合血红蛋白的反应比脱氧血红蛋白快得多。
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