Agyeman Kofi, McCarty Tristan, Multani Harpreet, Mattingly Kamryn, Koziar Katherine, Chu Jason, Liu Charles, Kokkoni Elena, Christopoulos Vassilios
Department of Bioengineering, University of California, Riverside, Riverside, CA, United States.
Neuroscience Graduate Program, University of California, Riverside, Riverside, CA, United States.
Front Neurosci. 2023 Aug 16;17:1233990. doi: 10.3389/fnins.2023.1233990. eCollection 2023.
Infancy is characterized by rapid neurological transformations leading to consolidation of lifelong function capabilities. Studying the infant brain is crucial for understanding how these mechanisms develop during this sensitive period. We review the neuroimaging modalities used with infants in stimulus-induced activity paradigms specifically, for the unique opportunity the latter provide for assessment of brain function.
Conducted a systematic review of literature published between 1977-2021, via a comprehensive search of four major databases. Standardized appraisal tools and inclusion/exclusion criteria were set according to the PRISMA guidelines.
Two-hundred and thirteen papers met the criteria of the review process. The results show clear evidence of overall cumulative growth in the number of infant functional neuroimaging studies, with electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS) to be the most utilized and fastest growing modalities with behaving infants. However, there is a high level of exclusion rates associated with technical limitations, leading to limited motor control studies (about ) in this population.
Although the use of functional neuroimaging modalities with infants increases, there are impediments to effective adoption of existing technologies with this population. Developing new imaging modalities and experimental designs to monitor brain activity in awake and behaving infants is vital.
婴儿期的特点是神经系统快速转变，从而巩固终身功能能力。研究婴儿大脑对于理解这些机制在这一敏感期如何发展至关重要。我们特别回顾了在刺激诱导活动范式中用于婴儿的神经成像方式，因为后者为评估脑功能提供了独特的机会。
通过全面搜索四个主要数据库，对1977年至2021年发表的文献进行了系统综述。根据PRISMA指南设定了标准化评估工具和纳入/排除标准。
213篇论文符合综述过程的标准。结果显示，有明确证据表明婴儿功能性神经成像研究的数量总体呈累积增长，脑电图（EEG）和功能性近红外光谱（fNIRS）是在行为婴儿中使用最多且增长最快的方式。然而，由于技术限制，排除率较高，导致该人群中运动控制研究有限（约 ）。
尽管对婴儿使用功能性神经成像方式有所增加，但在该人群中有效采用现有技术存在障碍。开发新的成像方式和实验设计以监测清醒和行为婴儿的大脑活动至关重要。
