Morasso G, Costantini M, Viterbori P, Bonci F, Del Mastro L, Musso M, Garrone O, Venturini M
Department of Psychology, National Cancer Institute, L.go R.Benzi, 10, 16132, Genova, Italy.
Eur J Cancer. 2001 Jan;37(2):216-23. doi: 10.1016/s0959-8049(00)00390-7.
Prediction of delayed psychiatric disorders in breast cancer patients by using a screening procedure was investigated. Two questionnaires, the Psychological Distress Inventory and the Hospital Anxiety and Depression Scale, were administered before and during chemotherapy, and at the first follow-up visit. A psychiatric diagnosis was assigned to 50 of the 132 patients (38%) evaluated at follow-up. Including a set of clinical and demographic variables in a logistic regression, increasing age (P=0.001) and psychiatric history (P<0.001) were associated with psychiatric morbidity at follow-up. The accuracy of the two questionnaires in predicting delayed psychiatric disorders increased from the evaluation before chemotherapy to the evaluation during chemotherapy. The most accurate prediction was observed for the concurrent evaluation at follow-up. The accuracy of three predictive models developed for each evaluation point by including age, psychiatric history and psychological distress measured with each of the two questionnaires was not significantly better than that observed using only the questionnaires' scores as predictors.
研究了通过筛查程序预测乳腺癌患者延迟性精神障碍的情况。在化疗前、化疗期间以及首次随访时，使用了两份问卷，即心理困扰量表和医院焦虑抑郁量表。在随访评估的132名患者中，有50名（38%）被诊断为患有精神疾病。将一组临床和人口统计学变量纳入逻辑回归分析，结果显示年龄增加（P=0.001）和有精神病史（P<0.001）与随访时的精神疾病发病率相关。两份问卷预测延迟性精神障碍的准确性从化疗前评估到化疗期间评估有所提高。随访时的同步评估显示预测最为准确。通过纳入年龄、精神病史以及用两份问卷各自测量的心理困扰而针对每个评估点建立的三个预测模型的准确性，并不显著优于仅使用问卷分数作为预测指标时所观察到的准确性。
