Urry R L, Dougherty K A
Fertil Steril. 1975 Mar;26(3):232-9. doi: 10.1016/s0015-0282(16)40992-1.
Seminiferous tubules from rats killed 24 hours after injection of pargyline, a monoamine oxidase inhibitor, did not grow well in tissue culture when compared to control tubules. Treated tubules showed severe tubular degeneration and loss of cellular detail after nine days in culture. Animals injected with pargyline for ten days had varying degrees of semi-niferous tubule degeneration with depletion of the spermatogenic elements. It is suggested that pargyline has a detrimental effect on spermatogenesis. Pargyline possibly acts by decreasing MAO levels which, in turn, may increase potentially damaging amines which may be responsible for the testicular damage.
与对照小管相比，注射单胺氧化酶抑制剂优降宁24小时后处死的大鼠的曲细精管在组织培养中生长不佳。培养九天后，处理过的小管显示出严重的小管变性和细胞细节丧失。注射优降宁十天的动物有不同程度的曲细精管变性，生精成分减少。提示优降宁对精子发生有有害作用。优降宁可能通过降低单胺氧化酶水平起作用，这反过来可能增加潜在的损伤性胺类，而这些胺类可能是睾丸损伤的原因。
