食欲素A可兴奋大鼠中缝背核的5-羟色胺能神经元。
Orexin A excites serotonergic neurons in the dorsal raphe nucleus of the rat.
作者信息
Brown R E, Sergeeva O, Eriksson K S, Haas H L
机构信息
Institut für Neurophysiologie, Heinrich-Heine-Universität, D-40001, Düsseldorf, Germany.
出版信息
Neuropharmacology. 2001 Mar;40(3):457-9. doi: 10.1016/s0028-3908(00)00178-7.
Abstract
Orexin A (10-300 nM) strongly excited dorsal raphe serotonergic neurons maintained in vitro. The depolarization persisted in the presence of tetrodotoxin (TTX, 0.5 microM) and was associated with an increase in input resistance. These results have relevance in the context of food intake regulation and the disease, narcolepsy.
摘要
食欲素A（10 - 300纳摩尔）能强烈兴奋体外培养的中缝背核5-羟色胺能神经元。在存在河豚毒素（TTX，0.5微摩尔）的情况下，去极化仍持续存在，且与输入电阻增加有关。这些结果与食物摄入调节及发作性睡病这一疾病相关。
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