Bouâouda Hanan, Jha Pawan Kumar
Pharmacology Institute, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany.
Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Front Neurosci. 2023 Aug 22;17:1230428. doi: 10.3389/fnins.2023.1230428. eCollection 2023.
Sleep-wake and fasting-feeding are tightly coupled behavioral states that require coordination between several brain regions. The mammalian lateral hypothalamus (LH) is a functionally and anatomically complex brain region harboring heterogeneous cell populations that regulate sleep, feeding, and energy metabolism. Significant attempts were made to understand the cellular and circuit bases of LH actions. Rapid advancements in genetic and electrophysiological manipulation help to understand the role of discrete LH cell populations. The opposing action of LH orexin/hypocretin and melanin-concentrating hormone (MCH) neurons on metabolic sensing and sleep-wake regulation make them the candidate to explore in detail. This review surveys the molecular, genetic, and neuronal components of orexin and MCH signaling in the regulation of sleep and metabolism.
睡眠-觉醒和禁食-进食是紧密关联的行为状态，需要多个脑区之间的协调。哺乳动物的外侧下丘脑（LH）是一个功能和解剖结构复杂的脑区，包含调节睡眠、进食和能量代谢的异质性细胞群。人们为了解LH作用的细胞和回路基础做出了重大努力。遗传和电生理操纵技术的快速发展有助于理解离散的LH细胞群的作用。LH中食欲素/下丘脑泌素和促黑素细胞激素（MCH）神经元在代谢感知和睡眠-觉醒调节上的相反作用，使其成为需要详细探索的对象。本文综述了食欲素和MCH信号在睡眠和代谢调节中的分子、遗传和神经元组成部分。
