N-甲基-D-天冬氨酸受体拮抗剂AP5和一氧化氮合酶抑制剂7-NI影响金鱼学习和记忆的不同阶段。

NMDA receptor antagonist AP5 and nitric oxide synthase inhibitor 7-NI affect different phases of learning and memory in goldfish.

作者信息

Xu X, Russell T, Bazner J, Hamilton J

机构信息

Department of Psychology, Grand Valley State University, 292 Au Sable Hall, 1 Campus Drive, Allendale, MI 49401, USA.

出版信息

Brain Res. 2001 Jan 19;889(1-2):274-7. doi: 10.1016/s0006-8993(00)03216-9.

DOI:10.1016/s0006-8993(00)03216-9

PMID:11166719

Abstract

The present study investigated the amnestic effects of N-methyl-D-aspartate (NMDA) receptor antagonist AP5 and nitric oxide (NO) synthase inhibitor 7-NI in avoidance conditioning in goldfish. The results showed that both AP5 and 7-NI, without impairing performance processes, produced anterograde amnesia when given before training. Furthermore, 7-NI produced retrograde amnesia when given immediately following training while AP5 did not. Thus, AP5 and 7-NI affected different phases of learning and memory.

摘要

本研究调查了N-甲基-D-天冬氨酸（NMDA）受体拮抗剂AP5和一氧化氮（NO）合酶抑制剂7-NI对金鱼回避条件反射的遗忘作用。结果表明，AP5和7-NI在不损害行为表现过程的情况下，在训练前给予时会产生顺行性遗忘。此外，7-NI在训练后立即给予时会产生逆行性遗忘，而AP5则不会。因此，AP5和7-NI影响学习和记忆的不同阶段。