Klipstein F A, Corcino J J
Gastroenterology. 1975 Feb;68(2):239-44.
The absorption of seven amino acids from an equimolar mixture containing each of the eight essential amino acids in a concentration of 20 mM was evaluated using a marker perfusion technique in 9 patients with untreated tropical sprue and in 6 healthy Puerto Rican control subjects. The rate of absorption of from two to six of the amino acids tested was lower in 7 of the patients than in the control subjects. The absorption of isoleucine, leucine, valine, and threonine was significantly lower in the group of sprue patients than in the control subjects. Treatment of 4 patients with oral tetracycline for 2 weeks was associated with return of amino acid absorption to normal in the 3 persons who had improved intestinal function, as tested by other parameters. More prolonged treatment was required for normalization of amino acid absorption in the 4th patient. These observations indicate that the absorption of certain essential amino acids is reduced in some patients with untreated tropical sprue.
采用标记物灌注技术，对9例未经治疗的热带口炎性腹泻患者和6名健康的波多黎各对照者，评估了他们从含有20 mM浓度的8种必需氨基酸的等摩尔混合物中吸收7种氨基酸的情况。在7例患者中，所检测的2至6种氨基酸的吸收速率低于对照者。口炎性腹泻患者组中异亮氨酸、亮氨酸、缬氨酸和苏氨酸的吸收显著低于对照者。4例患者口服四环素治疗2周后，经其他参数检测，肠道功能改善的3人氨基酸吸收恢复正常。第4例患者的氨基酸吸收正常化需要更长时间的治疗。这些观察结果表明，一些未经治疗的热带口炎性腹泻患者某些必需氨基酸的吸收减少。
