Fleischer N K
Med Klin. 1976 Jul 30;71(31):1273-6.
Folic acid absoprtion was measured in 45 patients before and after folic acid treatment by means of a folate tolerance test in serum and red-blood-cell-folate. 10 healthy men recently returned from the tropics volunteered as controls. There is no significant difference in the folate-tolerance tests in serum. The difference is significant however in the red-blood-cell-folate, which is markedly lower with the patients before treatment and raises after folate-treatment to the normal value of the control group. As the transport of folic acid in the mucosa follows two steps it is taken that the disturbance is localized in the hydrolysis of polyglutamate to monoglutamate-folic acid.
通过血清叶酸耐受试验和红细胞叶酸试验，对45例患者在叶酸治疗前后的叶酸吸收情况进行了测定。10名刚从热带地区归来的健康男性自愿作为对照。血清叶酸耐受试验无显著差异。然而，红细胞叶酸试验结果差异显著，患者治疗前红细胞叶酸水平明显较低，叶酸治疗后升至对照组的正常水平。由于叶酸在黏膜中的转运分两步进行，因此认为干扰发生在多谷氨酸水解为单谷氨酸叶酸的过程中。
