Goumas G, Tentolouris C, Tousoulis D, Stefanadis C, Toutouzas P
Cardiology Unit, Hippokration Hospital, Athens University Medical School, Vas. Sofias 114, 11528, Athens, Greece.
Atherosclerosis. 2001 Feb 1;154(2):255-67. doi: 10.1016/s0021-9150(00)00736-x.
L-Arginine is the substrate for nitric oxide production. Endothelium dysfunction could be attributed to L-arginine deficiency or the presence of L-arginine endogenous inhibitors. This hypothesis leads to the assumption that provision of L-arginine could be the key for endothelial function improvement. Many studies have proven that L-arginine has a beneficial effect on endothelium dependent vasoreactivity, as well as on the interaction between vascular wall, platelets and leucocytes. Therefore, individuals with risk factors for atherosclerosis and patients with coronary artery disease or heart failure, could benefit from therapy with L-arginine.
L-精氨酸是一氧化氮生成的底物。内皮功能障碍可能归因于L-精氨酸缺乏或L-精氨酸内源性抑制剂的存在。这一假说导致这样一种假设，即补充L-精氨酸可能是改善内皮功能的关键。许多研究已证明，L-精氨酸对内皮依赖性血管反应性以及血管壁、血小板和白细胞之间的相互作用具有有益作用。因此，具有动脉粥样硬化危险因素的个体以及冠心病或心力衰竭患者可能从L-精氨酸治疗中获益。
