Shir Y, Zeltser R, Vatine J J, Carmi G, Belfer I, Zangen A, Overstreet D, Raber P, Seltzer Z
Department of Anesthesiology and Pain Relief Unit, Hadassah University Hospital, Jerusalem, Israel.
Pain. 2001 Feb 1;90(1-2):75-82. doi: 10.1016/s0304-3959(00)00388-2.
In some rat strains, total hindpaw denervation triggers autotomy, a behavior of self mutilation presumably related to neuropathic pain. Partial sciatic ligation (PSL) in rats produces tactile allodynia and heat hyperalgesia but not autotomy. Our aims in this study were to examine: (1) whether sensibility of intact rats to noxious and non-noxious stimuli is strain-dependent; (2) whether sensibility of intact rats could predict levels of autotomy, or of allodynia and hyperalgesia in the PSL model; and (3) whether autotomy levels are correlated with levels of allodynia or hyperalgesia. Here we report that in two inbred rat strains (Lewis and Fisher 344), two outbred rat strains (Sabra and Sprague-Dawley) and four selection lines of rats (Genetically Epilepsy-Prone Rats, High Autotomy, Low Autotomy and Flinders Sensitive Line), tactile sensitivity and response duration to noxious heat of intact animals were strain-dependent. Levels of autotomy following hindpaw denervation and of allodynia and hyperalgesia in the PSL model were also strain-dependent. Thus, these traits are determined in part by genetic factors. Sensory sensibility of intact rats was not correlated with levels of autotomy following total denervation, or allodynia and hyperalgesia following partial denervation. We suggest that preoperative sensibility of intact rats is not a predictor of levels of neuropathic disorders following nerve injury. Likewise, no correlation was found between autotomy, allodynia and hyperalgesia, suggesting that neuropathic pain behaviors triggered by nerve injury of different etiologies are mediated by differing mechanisms.
在某些大鼠品系中，后爪完全去神经支配会引发自残行为，这种自我伤害行为可能与神经性疼痛有关。大鼠坐骨神经部分结扎（PSL）会产生触觉异常性疼痛和热痛觉过敏，但不会引发自残行为。本研究的目的是探讨：（1）未受伤大鼠对有害和无害刺激的敏感性是否具有品系依赖性；（2）未受伤大鼠的敏感性是否能够预测自残行为的程度，或PSL模型中异常性疼痛和痛觉过敏的程度；（3）自残行为的程度是否与异常性疼痛或痛觉过敏的程度相关。在此我们报告，在两个近交系大鼠（Lewis和Fisher 344）、两个远交系大鼠（Sabra和Sprague-Dawley）以及四个大鼠选择品系（遗传性癫痫易感性大鼠、高自残率、低自残率和弗林德斯敏感品系）中，未受伤动物的触觉敏感性和对有害热刺激的反应持续时间具有品系依赖性。后爪去神经支配后的自残行为程度以及PSL模型中的异常性疼痛和痛觉过敏程度也具有品系依赖性。因此，这些特征部分由遗传因素决定。未受伤大鼠的感觉敏感性与完全去神经支配后的自残行为程度，或部分去神经支配后的异常性疼痛和痛觉过敏程度无关。我们认为，未受伤大鼠术前的敏感性并不能预测神经损伤后神经性疾病的程度。同样，在自残行为、异常性疼痛和痛觉过敏之间未发现相关性，这表明由不同病因的神经损伤引发的神经性疼痛行为是由不同机制介导的。
