子痫前期患者分娩时，蜕膜和胎盘组织中的血管内皮生长因子信使核糖核酸未发生改变。
VEGF mRNA is unaltered in decidual and placental tissues in preeclampsia at delivery.
作者信息
Ranheim T, Staff A C, Henriksen T
机构信息
Institute for Nutrition Research, Aker Hospital, Oslo, Norway.
出版信息
Acta Obstet Gynecol Scand. 2001 Feb;80(2):93-8. doi: 10.1034/j.1600-0412.2001.080002093.x.
BACKGROUND
VEGF (vascular endothelial growth factor) is a growth factor which is central in blood vessel formation. We wanted to determine whether the mRNA levels of VEGF are altered in preeclampsia in decidual and placental tissues compared to control pregnancies.
METHODS
Decidua basalis was obtained by vacuum aspiration during cesarean section in 25 preeclamptic and 19 uneventful pregnancies. Placental biopsies were taken immediately after delivery. Relative mRNA levels of VEGF were quantified and compared to those of the housekeeping gene beta-actin.
RESULTS
No statistically significant differences in VEGF mRNA levels were found between the preeclampsia and the control group for either the decidual or placental tissues. Furthermore, there were no significant differences between VEGF mRNA levels in the preeclamptic and control group with respect to gestational age of the women.
CONCLUSIONS
This study provides no evidence of abnormal VEGF expression at delivery in decidua basalis or placenta in pregnancies complicated by preeclampsia.
背景
血管内皮生长因子（VEGF）是血管形成过程中的核心生长因子。我们想确定与正常妊娠相比，子痫前期患者蜕膜和胎盘组织中VEGF的mRNA水平是否发生改变。
方法
在剖宫产时通过真空吸引获取25例子痫前期患者和19例正常妊娠患者的基蜕膜。分娩后立即进行胎盘活检。对VEGF的相对mRNA水平进行定量，并与管家基因β-肌动蛋白的水平进行比较。
结果
子痫前期组与对照组的蜕膜或胎盘组织中，VEGF mRNA水平均无统计学显著差异。此外，子痫前期组与对照组的VEGF mRNA水平在孕妇孕周方面也无显著差异。
结论
本研究没有证据表明子痫前期妊娠患者分娩时基蜕膜或胎盘中VEGF表达异常。
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