来自南蛇藤的抗氧化苯甲酰化黄烷-3-醇糖苷。

Antioxidant benzoylated flavan-3-ol glycoside from Celastrus orbiculatus.

作者信息

Hwang B Y, Kim H S, Lee J H, Hong Y S, Ro J S, Lee K S, Lee J J

机构信息

Anticancer Agent Research Laboratory, Korea Research Institute of Bioscience and Biotechnology, P.O. Box 115, Yusong, Taejon 305-600, Korea.

出版信息

J Nat Prod. 2001 Jan;64(1):82-4. doi: 10.1021/np000251l.

DOI:10.1021/np000251l

PMID:11170672

Abstract

A new flavan-3-ol glycoside, (-)-epicatechin-5-O-beta-D-glucosyl-3-benzoate (1), and two known compounds, (-)-epicatechin and (-)-epiafzelechin, were isolated from an EtOAc extract of Celastrus orbiculatus aerial parts that exhibited significant antioxidant effect in a 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical assay. The structure of 1 was elucidated by spectroscopic analyses, and compound 1 and its aglycon, (-)-epicatechin-3-benzoate (2), were found to be moderately active as antioxidants in the DPPH assay.

摘要

从南蛇藤地上部分的乙酸乙酯提取物中分离出一种新的黄烷-3-醇糖苷，(-)-表儿茶素-5-O-β-D-葡萄糖基-3-苯甲酸酯（1），以及两种已知化合物，(-)-表儿茶素和(-)-表阿夫儿茶素。该提取物在1,1-二苯基-2-苦基肼（DPPH）自由基测定中表现出显著的抗氧化作用。通过光谱分析确定了1的结构，并且发现化合物1及其苷元(-)-表儿茶素-3-苯甲酸酯（2）在DPPH测定中作为抗氧化剂具有中等活性。